منابع مشابه
Mechanism of filopodia initiation by reorganization of a dendritic network
Afilopodium protrudes by elongation of bundled actin filaments in its core. However, the mechanism of filopodia initiation remains unknown. Using live-cell imaging with GFP-tagged proteins and correlative electron microscopy, we performed a kinetic-structural analysis of filopodial initiation in B16F1 melanoma cells. Filopodial bundles arose not by a specific nucleation event, but by reorganiza...
متن کاملTRPV1 expression-dependent initiation and regulation of filopodia.
Transient receptor potential vanilloid subtype 1 (TRPV1), a non-selective cation channel, is present endogenously in dorsal root ganglia (DRG) neurons. It is involved in the recognition of various pain producing physical and chemical stimuli. In this work, we demonstrate that expression of TRPV1 induces neurite-like structures and filopodia and that the expressed protein is localized at the fil...
متن کاملFilopodia
What are they? Filopodia are thin, dynamic cell extensions comprising tight bundles of long actin filaments covered with cell membrane. They can change their length rapidly, span many cell diameters, and interact with other cells. Sometimes the name filopodia is used more broadly to describe a range of cytoskeletal protrusions including thick filopodia, cell feet, and amoebae pseudopods. These ...
متن کاملLinking actin networks and cell membrane via a reaction-diffusion-elastic description of nonlinear filopodia initiation.
Reaction-diffusion models have been used to describe pattern formation on the cellular scale, and traditionally do not include feedback between cellular shape changes and biochemical reactions. We introduce here a distinct reaction-diffusion-elasticity approach: The reaction-diffusion part describes bistability between two actin orientations, coupled to the elastic energy of the cell membrane d...
متن کاملWRP Facilitates Filopodia Protrusion
Deformation of the plasma membrane—an early event in endocytosis and protrusion—is often produced by proteins containing BAR domains. These domains form curved structures that interact electrostatically with membrane lipids, causing the membrane to curve. Many such proteins also interact with proteins involved in regulation of actin polymerization, and thus they help to coordinate cytoskeletal ...
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ژورنال
عنوان ژورنال: Cell Adhesion & Migration
سال: 2011
ISSN: 1933-6918,1933-6926
DOI: 10.4161/cam.5.5.16971